|
KMID : 0043320120350111919
|
|
Archives of Pharmacal Research
2012 Volume.35 No. 11 p.1919 ~ p.1926
|
|
|
A new triterpenoid from Alisma orientale and their antibacterial effect
|
|
Jin Hong-Guang
Jin Qinglong
Kim A.-Ryun
Choi Hye-Min
Lee Je-Hyun
Kim Yeong-Shik
Lee Dong-Gun
Woo Eun-Rhan
|
|
|
Abstract
|
|
|
|
A new triterpenoid, named alisol Q 23-acetate, as well as fourteen known terpenes, alisol B 23-acetate (2), alisol B (3), alismol (4), 10-O-methyl-alismoxide (5), alismoxide (6), 11-deoxyalisol C (7), 13β,17β-epoxyalisol B 23-acetate (8), 4β,12-dihydroxyguaian-6,10-diene (9), alisol C 23-acetate (10), alisolide (11), 16β-methoxyalisol B monoacetate (12), alisol A (13), 16β-hydroxyalisol B 23-acetate (14), alisol A 24-acetate (15) were isolated from the rhizomes of Alisma orientale. The structures of compounds (1?15) were identified based on 1D and 2D NMR, including 1H-1H COSY, HSQC, HMBC and NOESY spectroscopic analyses. Among these isolates, antibacterial effect of compounds 2, 3, 10, and 15, major constituents of A. orientale was examined. The MIC values of compounds 2, 10, and 15 were 5?10 βg/mL against eight antibiotic resistant strains, which were lower than those from the positive controls (MICs of chloramphenicol and ampicillin were 5?80 μg/mL). Therefore, compounds 2, 10 and 15 exhibited the potent antibacterial activity.
|
|
|
KEYWORD
|
|
|
Alisma orientale, Alismataceae, Triterpenoid, Alisol Q 23-acetate, Antibacterial effect
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|